Azaphilones: Their Role in Various Biological Activities

Azaphilones which can be isolated from various natural resources like fungi and plant have range of potent biological activities that can be exploited against various diseases. Structure of numerous azaphilones has already been described. The present review talks about activities of azaphilones like anti cancerous, anti HIV, anti nematicidal, anti-bacterial, antifungal which have been extensively explored and efforts are going on to use azaphilones in drug formulation. This review is an effort to shift focus from complex synthetic products to natural products which are known to have to less toxicity and have less side effect for the treatment of various diseases

Fungi have been used for medical purposes for a long time. Fungal kingdom appears to be very rich and diverse in area of secondary metabolites. Fungi have evolved its secondary metabolic pathways in such a way producing various compounds having diverse array of biological activities. The chemical composition and biochemical activity of many fungi has not been yet studied in detail. Identification of novel herbal compounds and further to explore its wide range potential secondary metabolite has become a trend in the last decade. Speaking of that, more and more novel azaphilones are being identified and is being used in drug formulation. Azaphilones has shown a wide spectrum of biological activities against various target organisms, including bacteria, fungi, and nematodes including the anti-cancerous and anti-HIV activity, lipogenase activity and recently it has been reported that reported that azaphilones inhibit tau aggregation and dissolve tau aggregates. Concerning the pharmaceutical science, finding new secondary metabolites enriches the possibilities of new drug discovery.

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Annie Grace Sarah

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Asian Journal of Biomedical and Pharmaceutical Sciences