The tumor cells expressed Sall4, glypican-3, and alpha-fetoprotein in an immunohistochemically test. A recurrent liver tumor was treated with VIP chemotherapy, which resulted in complete pathological remission. Using this YST's PDX line, a drug-response assay demonstrated that gemcitabine and VIP both inhibit tumor growth. For rare cancers, it is difficult to obtain data on drug responses. Therefore, other available information, such as drug response data for tumors that frequently develop in other organs with identical or similar genetic or histological features to the target rare cancer and previous case reports of the same tumor type, can be used to select an appropriate chemotherapeutic regimen for rare cancers. Pancreatic yolk sac tumors are extremely uncommon, with only one previous radiological report and no comprehensive pathological description. YST is a malignant germ cell tumor that differentiates to resemble extraembryonic structures like the yolk sac, allantois, and extraembryonic mesenchyme, as defined by the WHO classification of testicular germ cell tumors. Histological growth patterns that YSTs exhibit include microcystic, myxomatous, solid, glandular, endodermal sinus, hepatoid, and others. GCTs typically manifest most frequently in the gonads of children and young adults. GCTs, on the other hand, are not limited to the gonads and frequently develop in the mediastinum, retroperitoneum, intracranial regions, and sacrococcygeal region. Other organs, including the liver, kidney, stomach, and pancreas, can have tumors that are similar to GCT, primarily YSTs and choriocarcinomas. These GCT-like tumors are more prevalent in middle-aged and older adults than normal GCT. The patient, who was 25 years old, presented with a massive seminoma that weighed approximately 2.6 kilograms. The distributions of histological tissue types in this enormous seminoma were thoroughly investigated by us. Seminoma components constituted the majority of the tumor. Additionally, the seminoma mass's root contained extremely small fragments of an embryonal carcinoma and yolk sac tumor. This demonstrates that additional embryonic components of the large seminoma may have been discovered through extensive histological examination. This may indicate that, in a different manner than the original mixed cell germ tumor, leaving the seminoma to grow may generate the other embryonic tumor component, which is not always large enough to be detected during a routine procedure. Primary tumors make up most uterine cervix adenocarcinomas. A case of pancreatic cancer that spread to the uterine cervix is the subject of this report. The patient, a 77-year-old Jehovah's Witness, had been diagnosed with pancreatic cancer ten years earlier. The tumor only underwent segmental excision, followed by radiofrequency wave therapy and chemotherapy because she had refused a blood transfusion for religious reasons. During a standard wellbeing assessment 6 years after her pancreatic growth resection, a cancer in the left lower curve of her lung was found, and afterward eliminated. Her serum CA19-9 level went up three years after the lung surgery. Tumors were found in the ascending colon and uterine cervix after a thorough examination. After an endocervical cytology, endocervical biopsy, and right hemicolectomy, she received chemotherapy and radiotherapy. She is alive today, roughly ten years after receiving her initial diagnosis, and there are no signs of recurrence or metastatic disease.

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With Regards,
Sara Giselle
Associate Managing Editor
Journal of Critical Care Obsestrics & Gynocology